PHOTON THERAPY FOR PROSTATE CANCER

Definitive Photon Therapy for Prostate Cancer: Age Does Not Affect Treatment Outcomes or Morbidity

Purpose/Objective(s)

PHOTON THERAPY FOR PROSTATE CANCER-External beam radiation photon therapy for prostate cancer(XRT) is associate accepted curative treatment choice for men with localized glandular cancer. This cohort of patients might embrace those of wide disparate written account ages. As age might influence treatment, morbidity, and response, we tend to examined and compared treatment technique and outcome for older and younger men treated for this designation.

Materials/Methods

PHOTON THERAPY FOR PROSTATE CANCER-An institutional review board–approved chart review of our institution’s information of definitive RT for localized glandular cancer came back 416 patients treated throughout 2009 to 2011. Age ranged from forty nine to eighty eight years, with seven-membered aged sixty or less, thirty seventh aged sixty one to seventy, forty sixth aged seventy one to eighty, and Sep 11 aged bigger than eighty years. Stage was T1 in seventieth (n=292), T2 in pure gold (n=100), and T3 in third (n=13). The T stage wasn't noted in eleven patients. The Gleason score was half-dozen in forty seventh of patients, 7 in 38%, 8 in 8%, and nine in five-hitter. Hormones were delivered to forty first of patients. gauge boson radiation was delivered by intensity changed RT all told cases with ninety seven conjointly undergoing image steerage. Radiation dose was typically eighty one Gy. The mean body part dose was thirty two.7 Gy, and therefore the mean bladder dose was twenty eight.4 Gy. Only 7.5% of patients were rumored to possess whole-pelvic XRT.

Results

PHOTON THERAPY FOR PROSTATE CANCER-Patients are followed a mean of eleven.2 months (range one.5 – 35.1 months). Acute reproductive organ (GU) complications were delicate with eighty six reportable as Grade zero, 1, or 2. Acute channel (GI) complications were additionally delicate with eighty six reportable as grade zero, 1, or 2. No Late GU complications were reportable in ninetieth of men and no late GI complications were reportable in ninety six. solely third of patients had any treatment interruption. native failure has not been seen and ninety nine of patients ar alive finally follow-up. No deaths attributed to glandular cancer are reportable. On univariate analysis and examination age teams (<60, 61-70, 71-80, >80 years), no important variations ar noted in T stage, Gleason Score, treatment techniques or dose, GI or GU morbidity (acute or chronic), outcomes, or treatment break among alternative variables. A statistically important distinction pro the utilization of secretion blockade in patients older than seventy years (P<.03) was noted. There was organic chemistry failure in four patients (1%). solely Gleason Score foreseen considerably for organic chemistry failure (P=.03). There was no distinction once analyzing by T stage, dose, treatment field, or age.

Conclusion

PHOTON THERAPY FOR PROSTATE CANCER-Age mustn't be a serious determinant in delivering definitive gauge boson RT for localized glandular cancer. aged patients is treated identically to younger patients with the expectation of comparable outcomes. No increase in acute or chronic morbidity was noted supported age, and treatment breaks weren't associated with age. Outcomes seem identical in terms of unwellness management and cancer-specific survival. Older gentlemen were additional unremarkably treated with the addition of secretion blockade, tho' this could represent undertreatment of younger men in an effort to preserve sexual perform.